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Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Gene Name: | homeodomain interacting protein kinase 3 |
Family/Subfamily: | Protein Kinase , MNB/DYRK |
Synonyms: | HIPK3, ANPK, FIST, FIST3, Homolog of protein kinase YAK1, DYRK6, PKY, YAK1 |
Target Sequences: | NM_005734 NP_005725.3 Q9H422 |
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