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HIP1
huntingtin interacting protein 1
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
| Gene Name: | huntingtin interacting protein 1 |
| Synonyms: | HIP1, HIP-1, HIP-I, ILWEQ |
| Target Sequences: | NM_005338 NP_005329.3 O00291 |
Publications (11)
1
Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS. Molecular and cellular biology. 2001 21:7796-806.
[PubMed:11604514]
[PMC:PMC99949]
2
Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. Rao DS, Hyun TS, Kumar PD, Mizukami IF, Rubin MA, Lucas PC, Sanda MG, Ross TS. The Journal of clinical investigation. 2002 110:351-60.
[PubMed:12163454]
[PMC:PMC151092]
3
HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. Hyun TS, Rao DS, Saint-Dic D, Michael LE, Kumar PD, Bradley SV, Mizukami IF, Oravecz-Wilson KI, Ross TS. The Journal of biological chemistry. 2004 279:14294-306.
[PubMed:14732715]
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HIP1 Mouse anti-Human Monoclonal (1F12) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
HIP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
![HIP1 Antibody - Western blot of HIP1 protein in HeLa cell and rat brain lysates, using HIP1 [1E1] antibody.](https://lsbio-7d62.kxcdn.com/image2/hip1-antibody-clone-1e1-ls-c2686/3167_786643.jpg)
HIP1 Mouse anti-Human Monoclonal (1E1) Antibody
Rat, Human
IF, IHC, IP, WB
Unconjugated
0.1 ml/$386
HIP1 Mouse anti-Human Monoclonal (4B10) Antibody
Human
IF, IHC, IP, WB
Unconjugated
0.1 ml/$386
HIP1 Rabbit anti-Human Polyclonal (aa410-690) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
HIP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
HIP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HIP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
HIP1 Rabbit anti-Human Polyclonal (aa410-690) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
HIP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
HIP1 Rabbit anti-Human Polyclonal (aa725-775) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
HIP1 Rabbit anti-Human Polyclonal (aa987-1037) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
HIP1 Mouse anti-Human Monoclonal Antibody
Rat, Human
WB
Unconjugated
100 µl/$649
HIP1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
HIP1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
HIP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
HIP1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
HIP1 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
HIP1 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
HIP1 Rabbit anti-Human Polyclonal (aa338-387) Antibody
Human
WB
Unconjugated
100 µl/$424
HIP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HIP1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human
WB
Biotin Conjugated
100 µl/$469
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