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HGF / Hepatocyte Growth Factor
hepatocyte growth factor (hepapoietin A; scatter factor)
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
| Gene Name: | hepatocyte growth factor (hepapoietin A; scatter factor) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | HGF, DFNB39, Hepatocyte growth factor, Hepatopoeitin-A, Hepapoietin A, Hepatopoietin-A, Scatter factor), SF, F-TCF, HGFB, HPTA, Scatter factor |
| Target Sequences: | X16323 CAA34387.1 P14210 |
Publications (6)
1
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-ß in gastric tissue. Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB. Cancer research. 2014 74:2642-51. (WB; Human)
[Full Text Article]
[PubMed:24590056]
[PMC:PMC4158836]
2
Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Piao Y, Park SY, Henry V, Smith BD, Tiao N, Flynn DL, de Groot JF. Neuro-oncology. 2016 September;18:1230-41. (Human)
[Full Text Article]
[PubMed:26965451]
[PMC:PMC4998992]
Related Antibodies: LS-B4657.
3
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y Zaytseva, Kathleen L O'Connor, Craig W Vander Kooi, Side Liu, Qing-Bai She. Nature communications. 2019 August;10:3708. [Full Text Article]
[PubMed:31420553]
[PMC:PMC6697747]
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Neuroscience
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
Neuroscience
HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (7-2) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$495
Neuroscience
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa216-265) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa216-265) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
HGF / Hepatocyte Growth Factor Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA
Unconjugated
100 µl/$375; 200 µl/$473; 400 µl/$648
HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (aa200-494) (OTI2F3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (A10) Antibody
Human
IP, WB
Unconjugated
100 µg/$500
HGF / Hepatocyte Growth Factor Rabbit anti-Mouse Polyclonal (aa482-710) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa32-291) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$281; 200 µl/$311; 500 µl/$411; 1 ml/$461; 2 ml/$562; 5 ml/$962
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa521-554) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$564
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa431-480) Antibody
Human
WB
Unconjugated
100 µl/$424
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
HGF / Hepatocyte Growth Factor Rabbit anti-Dog Monoclonal (Preservative Free) (105) Antibody
Dog
ELISA
Unconjugated, Preservative Free
100 µl/$412
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal (aa495-728) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$300; 200 µl/$338; 500 µl/$466; 1 ml/$530; 2 ml/$688; 5 ml/$1,149
HGF / Hepatocyte Growth Factor Rabbit anti-Rat Monoclonal (Preservative Free) (052) Antibody
Rat
ELISA
Unconjugated, Preservative Free
100 µl/$412
HGF / Hepatocyte Growth Factor Mouse anti-Human Monoclonal (aa200-494) (OTI3F2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Fast Shipping
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
HGF / Hepatocyte Growth Factor Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
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