HEXB

hexosaminidase B (beta polypeptide)

Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

HEXB (10)

Publications

No (10)

Tag

GST (1)

His (5)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (3)

Rat (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human HEXB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80748

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.9 kDa

Price:

20 µg/$150

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Human HEXB Protein (Recombinant His) (aa122-311) - LS-G12542

Source:

E. coli

Tag:

His

Molecular Weight:

22.9 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Mouse HEXB Protein (Recombinant His) (Met1-Ile536) - LS-G98173

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

59.4 kDa

Price:

100 µg/$843

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Human HEXB Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67799

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.9 kDa

Price:

20 µg/$1,107

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HEXB Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123132

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.9 kDa

Price:

100 µg/$494

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Rat HEXB Protein (Recombinant His-T7) (aa100-216) - LS-G24071

Source:

E. coli

Tag:

His-T7

Molecular Weight:

17.1 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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Human HEXB Protein (Recombinant GST) (Full Length) - LS-G28812

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.5 kDa

Price:

2 µg/$439

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Human HEXB Protein (Recombinant His) (aa315-456) - LS-G12534

Source:

E. coli

Tag:

His

Molecular Weight:

17.8 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Mouse HEXB Protein (Recombinant His) (aa101-217) - LS-G12540

Source:

E. coli

Tag:

His

Molecular Weight:

14.7 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse HEXB Protein (Recombinant His) (aa294-435) - LS-G12541

Source:

E. coli

Tag:

His

Molecular Weight:

17.9 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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