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HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
Gene Name: | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
Synonyms: | HERC6, Hect domain and RLD 6, Potential ubiquitin ligase |
Target Sequences: | AK000644 NP_060382.3 Q8IVU3 |
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