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E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8.
Gene Name: | HECT domain containing E3 ubiquitin protein ligase 3 |
Synonyms: | HECTD3, HECT domain containing 3, RP11-69J16.1 |
Target Sequences: | NM_024602 NP_078878.3 Q5T447 |
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