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HDAC9

histone deacetylase 9

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Gene Name: histone deacetylase 9
Family/Subfamily: Histone Deacetylase , not assigned-Histone Deacetylase
Synonyms: HDAC9, HD7, HD9, HDAC, HDAC7B, HDAC9B, HDAC9FL, KIAA0744, HD7b, HDRP, Histone deacetylase 7B, Histone deacetylase 9, MITR
Target Sequences: NM_014707 NP_055522.1 Q9UKV0

Publications (2)

1
Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation. Deng X, Ewton DZ, Mercer SE, Friedman E. The Journal of biological chemistry. 2005 280:4894-905. [PubMed:15546868] Related Antibodies: LS-C96661.
2
Specific control of pancreatic endocrine - and -cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R. Diabetes. 2011 60:2861-71. [PubMed:21953612] [PMC:PMC3198089] Related Antibodies: LS-C96662.

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HDAC9 ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
HDAC9 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
HDAC9 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
HDAC9 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
HDAC9 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$669
HDAC9 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
1 Plate/$783
HDAC9 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).