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HDAC4

histone deacetylase 4

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Gene Name: histone deacetylase 4
Family/Subfamily: Histone Deacetylase , not assigned-Histone Deacetylase
Synonyms: HDAC4, BDMR, AHO3, Histone deacetylase A, HD4, HA6116, HDAC-A, HDACA, Histone deacetylase 4, HDAC-4, KIAA0288
Target Sequences: NM_006037 NP_006028.2 P56524

Publications (2)

1
The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms. Zeynep Busra Aksoy-Ozer, Ceylan Verda Bitirim, Belma Turan, Kamil Can Akcali. Biological trace element research. 2024 January; [Full Text Article] [PubMed:38221603]
2
Inhibition of histone deacetylase 4 increases cytotoxicity of docetaxel in gastric cancer cells. Colarossi L, Memeo L, Colarossi C, Aiello E, Iuppa A, Espina V, Liotta L, Mueller C. Proteomics. Clinical applications. Dec;8:924-31. [Full Text Article] [PubMed:25091122] Related Antibodies: LS-B2033.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
HDAC4 (8)
No (8)
GST (1)
GST, N-terminus (2)
His-S (1)
Myc-DDK (Flag) (3)
Human (6)
Mouse (1)
293T Cells (1)
Baculovirus (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
HDAC4 Protein - 12.5% SDS-PAGE of human HDAC4 stained with Coomassie Blue
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Wheat Germ Extract
GST
132.8 kDa
10 µg/$479; 25 µg/$670
HDAC4 Protein - Purified recombinant protein HDAC4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
118.9 kDa
20 µg/$1,107
HDAC4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HDAC4 Protein
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E. coli
GST, N-terminus
53.7 kD
100 µg/$420; 20 µg/$323; 1 mg/$1,355
HDAC4 Protein - Recombinant Histone Deacetylase 4 By SDS-PAGE
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E. coli
His-S
26.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
HDAC4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
118.9 kDa
20 µg/$215
HDAC4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
118.9 kDa
100 µg/$710
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Baculovirus
None
Less than 1.0 EU/µg protein (determined by LAL method).
50.9 kDa
100 µg/$843
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).