HCK

hemopoietic cell kinase

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

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Proteins (11)

Type

Over-Expression Lysate (6)

Recombinant (5)

Target

HCK (11)

Publications

No (11)

Tag

GST (1)

GST, N-terminus (1)

His-S (2)

Myc-DDK (Flag) (7)

Species

Human (7)

Mouse (1)

Source

293T Cells (3)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human HCK Protein (Recombinant His-S) (aa2-526) - LS-G24915

Source:

E. coli

Tag:

His-S

Molecular Weight:

63.2 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human HCK Protein (Recombinant GST, N-terminus) (aa1-80) - LS-G58824

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HCK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67236

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.4 kDa

Price:

20 µg/$1,107

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Mouse HCK Protein (Recombinant His-S) (aa2-524) - LS-G24916

Source:

E. coli

Tag:

His-S

Molecular Weight:

62.7 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Human HCK Protein (Recombinant GST) (Full Length) - LS-G28804

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.29 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HCK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79395

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$150

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Human HCK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79396

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

20 µg/$150

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Human HCK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79397

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.6 kDa

Price:

20 µg/$150

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HCK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129933

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.9 kDa

Price:

100 µg/$494

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HCK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129967

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

100 µg/$494

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HCK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118182

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.6 kDa

Price:

100 µg/$494

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