HCK

hemopoietic cell kinase

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

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Products

Antibodies (79)

Proteins (11)

ELISA Kits (1)

Type

Over-Expression Lysate (6)

Primary (79)

Recombinant (5)

Sandwich (1)

Target

HCK (91)

Reactivity

Human (72)

Mouse (42)

Rat (13)

Chimpanzee (3)

Monkey (3)

Application

IHC (19)

IHC-P (4)

WB (73)

Flo (6)

ELISA (36)

ICC (1)

IF (11)

IP (1)

Peptide-ELISA (3)

Host

rabbit (66)

mouse (12)

rat (1)

Product Group

IHCPlus (1)

Isotype

IgG (41)

IgG1 (3)

IgG1,k (2)

IgG2a (1)

IgG2a,k (6)

Clonality

monoclonal mc (12)

polyclonal pc (67)

Clone

1508CT602.13.1 (1)

1D9-1A9 (1)

3D12E10 (2)

Format

96-Well Strip Plate (1)

APC (2)

APC Conjugated (7)

Azide-free (3)

Biotin Conjugated (8)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (8)

HRP Conjugated (8)

PE Conjugated (7)

Unconjugated (37)

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Epitope

aa2-524 (8)

aa2-526 (8)

aa1-30 (7)

aa131-156 (7)

aa72-101 (7)

aa295-344 (4)

350-430 aa (2)

pTyr410 (2)

450-530 aa (1)

aa1-220 (1)

aa1-80 (1)

aa22-80 (1)

aa381-430 (1)

pTyr521 (1)

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Publications

No (91)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

His-S (2)

Myc-DDK (Flag) (7)

Species

Human (7)

Mouse (1)

Source

293T Cells (3)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

HCK Antibody (aa131-156) LS-C166814

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

HCK Antibody (aa72-101) LS-C164398

Antibody:

HCK Rabbit anti-Mouse Polyclonal (aa72-101) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

HCK Antibody (clone 3D12E10) LS-C41517

Antibody:

HCK Mouse anti-Human Monoclonal (3D12E10) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$467

Select

HCK Antibody (450-530 aa) LS-C381088

Antibody:

HCK Rabbit anti-Human Polyclonal (450-530 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HCK Antibody (aa22-80) LS-C36599

Antibody:

HCK Rat anti-Human Monoclonal (aa22-80) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$896

Select

HCK Antibody (350-430 aa) LS-C383895

Antibody:

HCK Rabbit anti-Human Polyclonal (350-430 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HCK Antibody (aa131-156) LS-C321895

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

HCK Antibody (aa131-156, Biotin) LS-C258328

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

HCK Antibody (aa131-156, FITC) LS-C258329

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

HCK Antibody (aa131-156, APC) LS-C258327

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

HCK Antibody (aa131-156, Azide-free, HRP) LS-C258332

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

HCK Antibody (aa131-156, PE) LS-C258333

Antibody:

HCK Rabbit anti-Human Polyclonal (aa131-156) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

HCK Antibody (aa295-344) LS-B14030

Antibody:

HCK Rabbit anti-Human Polyclonal (aa295-344) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

Human HCK Protein (Recombinant His-S) (aa2-526) - LS-G24915

Source:

E. coli

Tag:

His-S

Molecular Weight:

63.2 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

Select

HCK Antibody (350-430 aa) LS-C381766

Antibody:

HCK Rabbit anti-Human Polyclonal (350-430 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

HCK Antibody LS-C822362

Antibody:

HCK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

HCK Antibody LS-C331879

Antibody:

HCK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

HCK Antibody LS-C813978

Antibody:

HCK Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

HCK Antibody LS-C668069

Antibody:

HCK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

HCK Antibody (aa381-430) LS-C117904

Antibody:

HCK Rabbit anti-Human Polyclonal (aa381-430) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

HCK Antibody LS-C666091

Antibody:

HCK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

HCK Antibody (clone 1508CT602.13.1) LS-C392565

Antibody:

HCK Mouse anti-Human Monoclonal (1508CT602.13.1) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

HCK Antibody (aa1-220) LS-C375890

Antibody:

HCK Rabbit anti-Human Polyclonal (aa1-220) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

HCK Antibody (clone 1D9-1A9) LS-C197400

Antibody:

HCK Mouse anti-Human Monoclonal (1D9-1A9) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

HCK Antibody (clone 3D12E10) LS-C758509

Antibody:

HCK Mouse anti-Human Monoclonal (3D12E10) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$518

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