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May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD.
Gene Name: | vacuolar protein sorting 53 homolog (S. cerevisiae) |
Synonyms: | VPS53, HCCS1, HVps53L, Pp13624 |
Target Sequences: | NM_018289 NP_060759.2 Q5VIR6 |
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