HBXIP

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

HBXIP (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human HBXIP Protein (Recombinant GST) (Full Length) - LS-G32212

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.75 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HBXIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80407

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18 kDa

Price:

20 µg/$150

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HBXIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100807

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18 kDa

Price:

100 µg/$494

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Human HBXIP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67661

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18 kDa

Price:

20 µg/$1,107

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Human HBXIP Protein (Recombinant His) - LS-G1866

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human HBXIP Protein (Recombinant GST, N-terminus) - LS-G64220

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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