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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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HBXIP
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
| Gene Name: | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
| Synonyms: | LAMTOR5, HBXIP, XIP |
| Target Sequences: | NM_006402 NP_006393.2 O43504 |
Publications (1)
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