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HBXIP

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Gene Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Synonyms: LAMTOR5, HBXIP, XIP
Target Sequences: NM_006402 NP_006393.2 O43504

Publications (1)

1
miRNA-548p suppresses hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein hepatitis B x-interacting protein. Xiu-Mei Hu, Xiao-Hui Yan, Yan-Wei Hu, Jin-Lan Huang, Shun-Wang Cao, Ting-Yu Ren, Yue-Ting Tang, Li Lin, Lei Zheng, Qian Wang. Hepatology research : the official journal of the Japan Society of Hepatology. 2016 July;46:804-15. [Full Text Article] [PubMed:26583881] Related Antibodies: LS-C111379.

☰ Filters
Antibodies (18)
Proteins (6)
ELISA Kits (5)
Custom (3)
Over-Expression Lysate (2)
Primary (18)
Recombinant (4)
Sandwich (2)
HBXIP (29)
Human (20)
Mouse (5)
Rat (1)
Pig (1)
IHC (5)
IHC-P (2)
WB (15)
ELISA (5)
Peptide-ELISA (1)
rabbit (18)
Product Group
IHCPlus (1)
IgG (12)
polyclonal pc (18)
96-Well Strip Plate (5)
APC Conjugated (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (10)
N-Terminus (4)
No (28)
Yes (1)
Plasma (2)
Serum (2)
Tissue Homogenates (1)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBXIP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBXIP Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBXIP Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
HBXIP Antibody - HBXIP antibody Western blot of Transfected 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HBXIP Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
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HBXIP Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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HBXIP Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
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HBXIP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
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HBXIP Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
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HBXIP Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
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HBXIP Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
HBXIP Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC-P, WB
Unconjugated
50 µl/$460
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HBXIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
HBXIP Antibody - Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100
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HBXIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
HBXIP Antibody - 1:100 staining human lymph carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HBXIP Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using LAMTOR5 Polyclonal Antibody at dilution of 1:55(×200)
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HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HBXIP Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer tissue  using LAMTOR5 Polyclonal Antibody at dilution of 1:35(×200)
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HBXIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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HBXIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
HBXIP Antibody
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HBXIP Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
HBXIP ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HBXIP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HBXIP Protein - 12.5% SDS-PAGE of human HBXIP stained with Coomassie Blue
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Wheat Germ Extract
GST
35.75 kDa
10 µg/$479; 25 µg/$670
HBXIP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
18 kDa
20 µg/$150
HBXIP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
18 kDa
100 µg/$494
HBXIP Protein - Purified recombinant protein LAMTOR5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
18 kDa
20 µg/$1,107
HBXIP ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
Viewing 1-25 of 29 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).