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Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.
Gene Name: | Hemoglobin, Theta 1 |
Synonyms: | HBQ1, Hemoglobin theta-1 chain, Hemoglobin, theta 1, Hemoglobin subunit theta-1, Theta-1-globin |
Target Sequences: | NM_005331 NP_005322.1 P09105 |
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