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HBP17 / FGFBP1 is a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.
Gene Name: | fibroblast growth factor binding protein 1 |
Synonyms: | FGFBP1, 17 kDa HBGF-binding protein, FGF-BP, HBP17, FGF-binding protein 1, FGFBP-1, FGF-BP1, FGFBP |
Target Sequences: | NM_005130 NP_005121.1 Q14512 |
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