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HBEGF / HB EGF

heparin-binding EGF-like growth factor

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Gene Name: heparin-binding EGF-like growth factor
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: HBEGF, Dtr, DTS, DTSF, HEGFL, Diphtheria Toxin Receptor
Target Sequences: NM_001945 NP_001936.1 Q99075

Publications (1)

1
Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis. S Kim, M J Graham, R G Lee, L Yang, S Kim, V Subramanian, J D Layne, L Cai, R E Temel, D Shih, A J Lusis, J A Berliner, S Lee. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2019 March;29:306-315. [Full Text Article] [PubMed:30738642] [PMC:PMC6452438]

☰ Filters
Products
Proteins (15)
Over-Expression Lysate (2)
Recombinant (13)
HBEGF / HB EGF (15)
No (14)
Yes (1)
6His, C-terminus (2)
GST (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (11)
Mouse (2)
293T Cells (1)
CHO Cells (1)
E. coli (9)
HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (9)
Biologically active (8)
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
12-14 kDa (SDS-PAGE)
5 µg/$239; 25 µg/$286; 1 mg/$1,148
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
14 kDa (SDS-PAGE)
50 µg/$300; 10 µg/$253; 1 mg/$1,148
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
9.7 kDa
10 µg/$268; 50 µg/$349
HBEGF / HB EGF Protein
Select
E. coli
None
Biologically active
9.7 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
HBEGF / HB EGF Protein - 12.5% SDS-PAGE of human HBEGF stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.53 kDa
10 µg/$479; 25 µg/$670
HBEGF / HB EGF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
22.9 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
9.7 kDa
10 µg/$278; 1 mg/$1,470; 50 µg/$364
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
9.8 kDa
10 µg/$278; 1 mg/$1,475; 50 µg/$364
HBEGF / HB EGF Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.9 kDa
100 µg/$494
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 86 amino acid recombinant protein has a predicted molecular mass of approximately 9.7 kD. The DTT-reduced and non-reduced protein migrate at approximately 13 kD and 16 kD respectively by SDS-PAGE. The predicted N-terminal amino acid is Asp.
10 µg/$268; 25 µg/$306
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.1 kDa
10 µg/$248; 50 µg/$296
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.1kD
10 µg/$248; 50 µg/$295; 500 µg/$693; 1 mg/$995
HBEGF / HB EGF Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~10.1 kDa
50 µg/$291; 200 µg/$437; 1 mg/$1,123
HBEGF / HB EGF Protein - Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor By SDS-PAGE
Select
E. coli
His
17.2 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
HBEGF / HB EGF Protein - Recombinant Heparin Binding Epidermal Growth Factor Like Growth Factor By SDS-PAGE
Select
E. coli
His-T7
18.9 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).