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The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia.
Gene Name: | hemoglobin, delta |
Synonyms: | HBD, Delta-globin chain, Delta globin, Delta-globin, Hemoglobin subunit delta, Hemoglobin, delta, Hemoglobin delta chain |
Target Sequences: | P02042 P02042 |
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