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HBA2 / Hemoglobin Alpha 2

hemoglobin, alpha 2

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes the following five loci: 5'- zeta - pseudozeta - pseudoalpha-1 - alpha-2 - alpha-1 -3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1 respectively; some nondeletion alpha thalassemias have also been reported.

Gene Name: hemoglobin, alpha 2
Synonyms: HBA2, Alpha globin, Alpha-2 globin, HBH, Hemoglobin alpha chain, Hemoglobin A1c, Hemoglobin subunit alpha, Hemoglobin, alpha 2, Alpha-globin
Target Sequences: NM_000517 NP_000508.1 P69905

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
HBA2 / Hemoglobin Alpha 2 (5)
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GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
HBA2 / Hemoglobin Alpha 2 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
HBA2 / Hemoglobin Alpha 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
15.1 kDa
20 µg/$150
HBA2 / Hemoglobin Alpha 2 Protein - Purified recombinant protein HBA2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
15.1 kDa
20 µg/$1,107
HBA2 / Hemoglobin Alpha 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.1 kDa
100 µg/$494
HBA2 / Hemoglobin Alpha 2 Protein - 12.5% SDS-PAGE of human HBA2 stained with Coomassie Blue
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Wheat Germ Extract
GST
41.36 kDa
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).