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HAVCR2 / TIM-3

hepatitis A virus cellular receptor 2

HAVCR2 / TIM-3 belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Gene Name: hepatitis A virus cellular receptor 2
Synonyms: HAVCR2, HAVcr-2, KIM-3, Kidney injury molecule-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, T-cell membrane protein 3, TIM3, TIMD-3, T cell immunoglobulin mucin-3, CD366
Target Sequences: NM_032782 NP_116171.3 Q8TDQ0

Publications (3)

1
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma. Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y. Oncology letters. 2016 12:1519-1524. (WB; Human) [Full Text Article] [PubMed:27446463] [PMC:PMC4950894] Related Antibodies: LS-C55594.
2
Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human) [Full Text Article] [PubMed:26993768] [PMC:PMC5029649] Related Antibodies: LS-C107052.
3
Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D Sood, Hong Wang, Xinyan Zhao, Molly H Jenkins, Qingyong Ji, Youbin Wang, David P Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G Derner, Qi An, Christel Iffland, Joern-Peter Halle. Oncoimmunology. 2020 Apr;9:1744921. [Full Text Article] [PubMed:32313722] [PMC:PMC7153820] Related Antibodies: LS-C748494.

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ELISA Kits (10)
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HAVCR2 / TIM-3 (10)
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Plasma (7)
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HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$730
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
47 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HAVCR2 / TIM-3 ELISA Kit
Select
Sandwich
Human
31.2 - 2000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
HAVCR2 / TIM-3 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,276; 1000 Wells/$1,903
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HAVCR2 / TIM-3 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).