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HAVCR2 / TIM-3
hepatitis A virus cellular receptor 2
HAVCR2 / TIM-3 belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
| Gene Name: | hepatitis A virus cellular receptor 2 |
| Synonyms: | HAVCR2, HAVcr-2, KIM-3, Kidney injury molecule-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, T-cell membrane protein 3, TIM3, TIMD-3, T cell immunoglobulin mucin-3, CD366 |
| Target Sequences: | NM_032782 NP_116171.3 Q8TDQ0 |
Publications (3)
1
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma. Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y. Oncology letters. 2016 12:1519-1524. (WB; Human)
[Full Text Article]
[PubMed:27446463]
[PMC:PMC4950894]
Related Antibodies: LS-C55594.
2
Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes. Norström MM, Rådestad E, Sundberg B, Mattsson J, Henningsohn L, Levitsky V, Uhlin M. Oncotarget. 2016 7:23581-93. (Flo, ELISA; Human)
[Full Text Article]
[PubMed:26993768]
[PMC:PMC5029649]
Related Antibodies: LS-C107052.
3
Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D Sood, Hong Wang, Xinyan Zhao, Molly H Jenkins, Qingyong Ji, Youbin Wang, David P Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G Derner, Qi An, Christel Iffland, Joern-Peter Halle. Oncoimmunology. 2020 Apr;9:1744921. [Full Text Article]
[PubMed:32313722]
[PMC:PMC7153820]
Related Antibodies: LS-C748494.
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HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (APC) (F38-2E2) Antibody
Human
Flo
APC Conjugated
25 Tests/$315; 100 Tests/$442
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (aa176-194) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$495
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (RMT3-23) Antibody
Mouse
Flo, IF, IHC, IHC-Fr, IHC-P
Unconjugated
0.1 mg/$385
HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (aa22-202) (OTI2E2) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$450
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (25F.1D6) Antibody
Mouse
Flo, IHC
Unconjugated
250 µg/$421
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (FITC) (25F.1D6) Antibody
Mouse
Flo, IHC
FITC Conjugated
100 µg/$369
HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (GF1) Antibody
Human
Flo, WB
Unconjugated
100 µl/$786
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (RMT3-23) Antibody
Mouse
Flo
Unconjugated
50 µg/$285; 100 µg/$382; 500 µg/$476
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HAVCR2 / TIM-3 Goat anti-Human Polyclonal (aa225-236) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
E. coli
His, N-Terminal
100 µg/$361; 500 µg/$739; 20 µg/$261
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (FITC) (RMT3-23) Antibody
Mouse
Flo
FITC Conjugated
0.1 mg/$432
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.86kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$460
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (aa22-202) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Sandwich
96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$730
HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (2A7A6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (TI 142F) Antibody
Mouse
ELISA, Flo
Unconjugated
50 µg/$337; 100 µg/$386
HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (2A6) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$502
HAVCR2 / TIM-3 Mouse anti-Human Monoclonal (7C8A7) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
HAVCR2 / TIM-3 Rabbit anti-Mouse Polyclonal (aa100-200) Antibody
Mouse
WB
Unconjugated
0.1 mg/$386
HAVCR2 / TIM-3 Rat anti-Mouse Monoclonal (aa20-193) (PerCP) (11n191) Antibody
Mouse
Flo
PerCP Conjugated
100 Tests/$907
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal (aa22-202) Antibody
Pig, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
HAVCR2 / TIM-3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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