HAP1

huntingtin-associated protein 1

Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca2+ release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).

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Proteins (7)

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Over-Expression Lysate (4)

Recombinant (3)

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HAP1 (7)

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His-GST (2)

His-T7 (1)

Myc-DDK (Flag) (4)

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Human (3)

Mouse (1)

Rat (1)

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293T Cells (2)

E. coli (3)

HEK 293 Cells (2)

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Human HAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88069

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.5 kDa

Price:

20 µg/$215

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Human HAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88070

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.5 kDa

Price:

20 µg/$215

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HAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104813

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.5 kDa

Price:

100 µg/$710

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HAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120140

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

66.5 kDa

Price:

100 µg/$710

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Human HAP1 Protein (Recombinant His-GST) (aa160-381) - LS-G25937

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.9 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Mouse HAP1 Protein (Recombinant His-T7) (aa132-328) - LS-G25938

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Rat HAP1 Protein (Recombinant His-GST) (aa349-584) - LS-G25939

Source:

E. coli

Tag:

His-GST

Molecular Weight:

56.6 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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