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HAMP / Hepcidin

hepcidin antimicrobial peptide

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).

Gene Name: hepcidin antimicrobial peptide
Synonyms: HAMP, Hepcidin antimicrobial peptide, LEAP-1, LEAP1, HEPC, Hepcidin, HFE2B, PLTR, Putative liver tumor regressor
Target Sequences: NM_021175 NP_066998.1 P81172

Publications (6)

1
Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss. Hao-Han Guo , Lei Xiong , Jin-Xiu Pan, Daehoon Lee, Kevin Liu, Xiao Ren, Bo Wang, Xiao Yang, Shun Cui, Lin Mei, Wen-Cheng Xiong. Bone research. 2021 June;9:31. [Full Text Article] [PubMed:34108442] [PMC:PMC8190093]
2
Low Serum Hepcidin Is Associated With Reduced Short-Term Survival in Adults With Acute Liver Failure. Igor Spivak, Jyoti Arora, Caitlyn Meinzer, Valerie Durkalski-Mauldin, William M Lee, Christian Trautwein, Robert J Fontana, Pavel Strnad, Acute Liver Failure Study Group (ALFSG). Hepatology (Baltimore, Md.). 2019 May;69:2136-2149. [Full Text Article] [PubMed:30582749]
3
Development of a model for anemia of inflammation that is relevant to critical care. Margit Boshuizen, Robin van Bruggen, Sebastian A Zaat, Marcus J Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi, Nicole P Juffermans. Intensive care medicine experimental. 2019 July;7:47. [Full Text Article] [PubMed:31346819] [PMC:PMC6658638]
4
Iron Protein Succinylate in the Management of Iron Deficiency Anemia: A Comparative Study with Ferrous Sulphate at Low and High Therapeutic Doses. Katia Urso, Javier Leal Martínez-Bujanda, Jaime Moscoso Del Prado. Nutrients. 2021 Mar;13:968. [Full Text Article] [PubMed:33802720] [PMC:PMC8002401]
5
Tolerable upper intake level of iron damages the liver of weaned piglets. Haoxuan Ding, Yang Zhao, Xiaonan Yu, Lingjun Chen, Jianan Han, Jie Feng. Journal of animal physiology and animal nutrition. 2021 July;105:668-677. [Full Text Article] [PubMed:33683742] Related Antibodies: LS-C294486.
6
Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm. Paul Loick , Goran Hamid Mohammad , Ismail Cassimjee, Anirudh Chandrashekar, Pierfrancesco Lapolla, Alison Carrington, Mayra Vera-Aviles, Ashok Handa, Regent Lee , Samira Lakhal-Littleton. Arteriosclerosis, thrombosis, and vascular biology. 2023 May;43:713-725. [Full Text Article] [PubMed:36951059] [PMC:PMC10125116]
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Antibodies (78)
Primary (78)
HAMP / Hepcidin (78)
Human (42)
Mouse (16)
Rat (9)
Bovine (8)
Chimpanzee (3)
Cow (8)
Monkey (4)
Orangutan (3)
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Peptide-ELISA (2)
rabbit (68)
mouse (9)
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IHCPlus (3)
IgG (25)
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monoclonal mc (9)
polyclonal pc (69)
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aa23-82 (8)
aa23-84 (8)
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aa25-84 (8)
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aa17-46 (7)
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aa1-50 (1)
aa22-36 (1)
aa39-59 (1)
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HAMP / Hepcidin Antibody - Anti-HAMP / Hepcidin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HAMP / Hepcidin Mouse anti-Human Monoclonal (1F9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HAMP / Hepcidin Antibody - Anti-HAMP / Hepcidin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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HAMP / Hepcidin Goat anti-Human Polyclonal (aa22-36) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
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HAMP / Hepcidin Rabbit anti-Mouse Polyclonal (aa39-59) Antibody
Mouse
IHC, WB
Unconjugated
500 µg/$393
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HAMP / Hepcidin Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
DB, ELISA
Unconjugated
100 µg/$832
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA
Unconjugated
100 µg/$832
HAMP / Hepcidin Antibody - HAMP / Hepcidin antibody Western blot of Fetal Spleen lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
HAMP / Hepcidin Antibody - HAMP / Hepcidin antibody Western blot of Fetal Spleen lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (aa1-50) (HRP) Antibody
Human, Monkey, Chimpanzee, Orangutan
WB
HRP Conjugated
100 µl/$469
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$832
HAMP / Hepcidin Antibody - Western blot of recombinant HAMP / Hepcidin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HAMP / Hepcidin Rabbit anti-Pig Polyclonal (aa23-82) Antibody
Pig
WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
HAMP / Hepcidin Antibody - Western Blot; Sample: Recombinant Hepc, Mouse.
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HAMP / Hepcidin Rabbit anti-Mouse Polyclonal (aa24-83) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$603; 100 µl/$832
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$533; 100 µl/$832
HAMP / Hepcidin Antibody - Western blot of HAMP Antibody in MDA-MB435 cell line lysates (35 ug/lane). HAMP (arrow) was detected using the purified antibody.
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (aa17-46) Antibody
Human
WB
Unconjugated
400 µl/$393
HAMP / Hepcidin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HAMP / Hepcidin Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HAMP / Hepcidin Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HAMP / Hepcidin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
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HAMP / Hepcidin Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µl/$801
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HAMP / Hepcidin Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$832
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
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HAMP / Hepcidin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (aa17-46) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (aa17-46) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (aa17-46) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (aa17-46) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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HAMP / Hepcidin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).