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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Gene Name: | H2A histone family, member Y2 |
Synonyms: | H2AFY2, Core histone macroH2A2.2, Core histone macro-H2A.2, Histone macroH2A2, H2A histone family, member Y2, MH2A2, MacroH2A2 |
Target Sequences: | NM_018649 NP_061119.1 Q9P0M6 |
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