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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.
Gene Name: | H2A histone family, member Y |
Synonyms: | H2AFY, Core histone macro-H2A.1, Histone macroH2A1.1, H2A histone family, member Y, H2A.y, Histone H2A.y, MACROH2A1.1, MacroH2A1.2, H2AF12M, Histone macroH2A1.2, MACROH2A1, Histone macroH2A1, MH2A1 |
Target Sequences: | NM_004893 NP_004884.1 O75367 |
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