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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | granzyme M (lymphocyte met-ase 1) |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | GZMM, Granzyme M, Lymphocyte met-ase 1, Met-1 serine protease, MET1, Met-ase, Hu-Met-1, LMET1, Met-ASE 1 |
Target Sequences: | NM_005317 NP_005308.1 P51124 |
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