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GZMA / Granzyme A

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Gene Name: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Family/Subfamily: Protease , Serine S1
Synonyms: GZMA, CTLA3, CTL tryptase, Granzyme-1, H factor, HF, HFSP, Granzyme A, Fragmentin-1, Hanukah factor, Hanukkah factor
Target Sequences: NM_006144 NP_006135.1 P12544

Publications (5)

1
Lesional CD4+ IFN-?+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Maehara T, Mattoo H, Ohta M, Mahajan VS, Moriyama M, Yamauchi M, Drijvers J, Nakamura S, Stone JH, Pillai SS. Annals of the rheumatic diseases. 2017 February;76:377-385. (Human) [Full Text Article] [PubMed:27358392] [PMC:PMC5435236] Related Antibodies: LS-C312742.
2
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis. Takashi Maehara, Naoki Kaneko, Cory A Perugino, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Samuel Jh Murphy, Musie Ghebremichael, David Fox, Aimee S Payne, Robert Lafyatis, John H Stone, Dinesh Khanna, Shiv Pillai. The Journal of clinical investigation. 2020 May;130:2451-2464. [Full Text Article] [PubMed:31990684] [PMC:PMC7190971] Related Antibodies: LS-C312742.
3
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease. Cory A Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J H Murphy, Musie Ghebremichael, Zachary S Wallace, Marcy B Bolster, Liam M Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H Stone, Shiv Pillai. The Journal of allergy and clinical immunology. 2021 January;147:368-382. [Full Text Article] [PubMed:32485263] [PMC:PMC7704943] Related Antibodies: LS-C312742.
4
CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum. Hugues Allard-Chamard, Faisal Alsufyani, Naoki Kaneko, Kelly Xing, Cory Perugino, Vinay S Mahajan, Joseph L Wheat, George S Deepe Jr, James Loyd, Shiv Pillai. Journal of immunology (Baltimore, Md. : 1950). 2021 February;206:524-530. [Full Text Article] [PubMed:33328214] [PMC:PMC7978153] Related Antibodies: LS-C312742.
5
Cytotoxic CD8sup>+/sup> T cells may be drivers of tissue destruction in Sjögren's syndrome. Naoki Kaneko, Hu Chen, Cory A Perugino, Takashi Maehara, Ryusuke Munemura, Shiho Yokomizo, Junsei Sameshima, Thomas J Diefenbach, Katherine R Premo, Akira Chinju, Yuka Miyahara, Mizuki Sakamoto, Masafumi Moriyama, John H Stone, Seiji Nakamura, Shiv Pillai. Scientific reports. 2022 September;12:15427. [Full Text Article] [PubMed:36104369] [PMC:PMC9475031] Related Antibodies: LS-C312742.
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ELISA Kits (21)
Custom (2)
Development Kit (1)
Sandwich (17)
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GZMA / Granzyme A (21)
Human (9)
Mouse (5)
Rat (1)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
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12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (16)
Antibody Pair and Standard (1)
No (21)
Cell Culture Supernatants (4)
Cell Lysates (5)
Plasma (15)
Serum (15)
Tissue Homogenates (6)
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
GZMA / Granzyme A ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GZMA / Granzyme A ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
GZMA / Granzyme A ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Microplate
Human
6.14 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
GZMA / Granzyme A ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
GZMA / Granzyme A ELISA Kit
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Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).