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Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants.
Gene Name: | glycophorin C (Gerbich blood group) |
Synonyms: | GYPC, CD236, CD236 antigen, GLPC, Glycophorin-C, Glycoconnectin, Glycophorin C, GPC, GYPD, Sialoglycoprotein D, PAS-2, CD236R, GE, Glycophorin-D, Glycoprotein beta, GPD, PAS-2' |
Target Sequences: | NM_002101 NP_002092.1 P04921 |
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