GTPCH1 / GCH1

GTP cyclohydrolase 1

GTPCH1 / GCH1 is a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

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Proteins (6)

Type

Over-Expression Lysate (4)

Recombinant (2)

Target

GTPCH1 / GCH1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human GTPCH1 / GCH1 Protein (Recombinant GST) (Full Length) - LS-G28593

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.24 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GTPCH1 / GCH1 Protein (Recombinant GST, N-terminus) (aa84-172) - LS-G58667

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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GTPCH1 / GCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G98943

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.9 kDa

Price:

100 µg/$494

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Human GTPCH1 / GCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76313

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.9 kDa

Price:

20 µg/$150

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Human GTPCH1 / GCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76314

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.9 kDa

Price:

20 µg/$150

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GTPCH1 / GCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121150

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.9 kDa

Price:

100 µg/$494

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