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GTPCH1 / GCH1

GTP cyclohydrolase 1

GTPCH1 / GCH1 is a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.

Gene Name: GTP cyclohydrolase 1
Synonyms: GCH1, DYT14, DYT5a, Dystonia 14, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTPCH1, HPABH4B, GTP-CH-1, DYT5, GCH, GTP-CH-I
Target Sequences: NM_000161 NP_000152.1 P30793

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Products
Antibodies (45)
Primary (45)
GTPCH1 / GCH1 (45)
Human (45)
Mouse (6)
Rat (5)
Bat (4)
Bovine (7)
Chicken (4)
Chimpanzee (6)
Dog (7)
Gibbon (6)
Guinea pig (3)
Hamster (3)
Horse (4)
Monkey (4)
Pig (7)
Rabbit (6)
Xenopus (4)
IHC (25)
IHC-P (2)
WB (45)
ELISA (8)
IF (1)
IP (2)
Peptide-ELISA (2)
rabbit (24)
mouse (20)
goat (1)
IgG (15)
IgG1 (4)
IgG2a (14)
IgG2a,k (1)
monoclonal mc (19)
polyclonal pc (26)
4A12 (1)
OTI1A3 (2)
OTI1E3 (2)
OTI2D12 (2)
OTI2E2 (2)
OTI3A3 (2)
OTI3C9 (2)
OTI5A1 (2)
OTI7B8 (2)
OTI8C6 (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
Carrier-free (9)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (29)
aa39-67 (7)
C-Terminus (4)
aa39-88 (4)
aa150-161 (1)
aa50-100 (1)
No (45)
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GTPCH1 / GCH1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
GTPCH1 / GCH1 Antibody - Detection of human and mouse GCH1 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-GCH1 antibody used for WB at 0.1 µg/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
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GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$467
GTPCH1 / GCH1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GTPCH1 / GCH1 Goat anti-Human Polyclonal (aa150-161) Antibody
Xenopus, Chicken, Bovine, Bat, Pig, Horse, Dog, Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$503
GTPCH1 / GCH1 Antibody - GTPCH1 / GCH1 antibody Western Blot of Fetal Heart. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa39-88) Antibody
Human
WB
Unconjugated
100 µl/$424
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI3A3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3A3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI1E3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1E3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - GCH1 monoclonal antibody (M01), clone 4A12 Western blot of GCH1 expression in IMR-32.
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (4A12) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI1A3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI2E2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI2D12) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI7B8) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI7B8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human skin tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120 oC for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI5A1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human skin tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120 oC for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5A1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa39-67) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI3C9) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3C9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (OTI8C6) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
GTPCH1 / GCH1 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
Select
GTPCH1 / GCH1 Mouse anti-Human Monoclonal (Carrier-free) (OTI8C6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
GTPCH1 / GCH1 Antibody - GCH1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas followed by peroxidase-conjugated secondary antibody and DAB staining.
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GTPCH1 / GCH1 Rabbit anti-Human Polyclonal (aa39-67) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).