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RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.
Gene Name: | general transcription factor IIIC, polypeptide 6, alpha 35kDa |
Synonyms: | GTF3C6, C6orf51, BA397G5.3, TFIIIC35, TFIIIC 35 kDa subunit |
Target Sequences: | NM_138408 NP_612417.1 Q969F1 |
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