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GSTP1 / GST Pi

glutathione S-transferase pi 1

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Gene Name: glutathione S-transferase pi 1
Synonyms: GSTP1, Deafness, X-linked 7, DFN7, GSTP1-1, Glutathione S-transferase P, GST Pi, GSTP, FAEES3, Glutathione S-transferase pi 1, GST class-pi, GST3, PI
Target Sequences: NM_000852 NP_000843.1 P09211

Publications (5)

1
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. Cadoni E, Marongiu F, Fanti M, Serra M, Laconi E. Oncotarget. 2017 8:36020-36032. (WB; Rat) [Full Text Article] [PubMed:28415598] [PMC:PMC5482635]
2
Editor's Highlight: Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila. Vorojeikina D, Broberg K, Love TM, Davidson PW, van Wijngaarden E, Rand MD. Toxicological sciences : an official journal of the Society of Toxicology. 2017 May;157:211-221. (Human) [Full Text Article] [PubMed:28184905] [PMC:PMC5837650] Related Antibodies: LS-B2376.
3
Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Begolly S, Olschowka JA, Love T, Williams JP, O'Banion MK. Glia. 2018 April;66:846-861. [Full Text Article] [PubMed:29288597] [PMC:PMC5812816] Related Antibodies: LS-B2376.
4
Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex. Hidenori Tabata, Megumi Sasaki, Masakazu Agetsuma, Hitomi Sano, Yuki Hirota, Michio Miyajima, Kanehiro Hayashi, Takao Honda, Masashi Nishikawa, Yutaka Inaguma, Hidenori Ito, Hirohide Takebayashi, Masatsugu Ema, Kazuhiro Ikenaka, Junichi Nabekura, Koh-Ichi Nagata, Kazunori Nakajima. Nature communications. 2022 November;13:6571. [Full Text Article] [PubMed:36323680] [PMC:PMC9630450] Related Antibodies: LS-B2376.
5
Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. Kirpich IA, Gobejishvili LN, Bon Homme M, Waigel S, Cave M, Arteel G, Barve SS, McClain CJ, Deaciuc IV. The Journal of nutritional biochemistry. 2011 Jan;22:38-45. [Full Text Article] [PubMed:20303728] [PMC:PMC3860361] Related Antibodies: LS-B2376.
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Proteins (20)
Over-Expression Lysate (2)
Recombinant (18)
GSTP1 / GST Pi (20)
No (20)
6His, N-terminus (1)
GST (2)
His (9)
His, N-Terminal (1)
His-S (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Bovine (1)
Human (12)
Mouse (3)
Pig (1)
Rat (2)
293T Cells (1)
E. coli (15)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
Low endotoxin level (3)
Biologically active (1)
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E. coli
His
27.4 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
23.5 kDa
10 µg/$344; 50 µg/$584
GSTP1 / GST Pi Protein
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E. coli
His
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$411; 500 µg/$985; 20 µg/$276
GSTP1 / GST Pi Protein - Recombinant Glutathione S Transferase Pi By SDS-PAGE
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E. coli
His
24.5 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
23.5kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
GSTP1 / GST Pi Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$150
GSTP1 / GST Pi Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
100 µg/$494
GSTP1 / GST Pi Protein - Purified recombinant protein GSTP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$1,107
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E. coli
His-SUMO
39.5 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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E. coli
GST
50.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
His
27.3 kD
100 µg/$420; 20 µg/$323; 1 mg/$1,355
GSTP1 / GST Pi Protein
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Yeast
His
25.5 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
GSTP1 / GST Pi Protein - Recombinant  Glutathione S Transferase Pi By SDS-PAGE
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E. coli
His-S
27.2 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
GSTP1 / GST Pi Protein
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E. coli
6His, N-terminus
23 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
GSTP1 / GST Pi Protein - 12.5% SDS-PAGE of human GSTP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
48.84 kDa
10 µg/$479; 25 µg/$670
GSTP1 / GST Pi Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
GSTP1 / GST Pi Protein - Active Glutathione S Transferase Pi (GSTp) by WB
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E. coli
His, N-Terminal
25kDa
10 µg/$299; 50 µg/$552; 200 µg/$1,080; 100 µg/$882; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
GSTP1 / GST Pi Protein - Recombinant Glutathione S Transferase Pi By SDS-PAGE
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E. coli
His
24.7 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
GSTP1 / GST Pi Protein - Recombinant Glutathione S Transferase Pi By SDS-PAGE
Select
E. coli
His
24.9 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
Select
E. coli
His
24.9 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).