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Vector Laboratories, Inc.
6737 Mowry Ave
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GSTA3

glutathione S-transferase alpha 3

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.

Gene Name: glutathione S-transferase alpha 3
Synonyms: GSTA3, GST class-alpha member 3, GSTA3-3, Glutathione S-transferase A3, GTA3, Glutathione S-transferase A3-3
Target Sequences: NM_000847 NP_000838.3 Q16772

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
GSTA3 (8)
No (8)
GST (1)
His (3)
His-T7 (1)
Myc-DDK (Flag) (3)
Chicken (1)
Human (4)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
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E. coli
His
26.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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E. coli
His
26.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
GSTA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.1 kDa
20 µg/$150
GSTA3 Protein - Purified recombinant protein GSTA3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
25.1 kDa
20 µg/$1,107
GSTA3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
25.1 kDa
100 µg/$494
GSTA3 Protein - Recombinant Glutathione S Transferase Alpha 3 By SDS-PAGE
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E. coli
His-T7
30.0 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
GSTA3 Protein - 12.5% SDS-PAGE of human GSTA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.16 kDa
10 µg/$479; 25 µg/$670
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E. coli
His
26.5 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,881
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).