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Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency.
Gene Name: | glutathione synthetase |
Synonyms: | GSS, GSH-S, GSHS, Glutathione synthase, Glutathione synthetase, GSH synthetase |
Target Sequences: | NM_000178 NP_000169.1 P48637 |
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