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GSR / Glutathione Reductase is a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Gene Name: | glutathione reductase |
Synonyms: | GSR, GR, GLUR, GRase, Glutathione reductase, GRD1 |
Target Sequences: | NM_000637 NP_000628.2 P00390 |
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