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Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Gene Name: | G1 to S phase transition 2 |
Synonyms: | GSPT2, G1 to S phase transition 2, GST2, ERF3B |
Target Sequences: | NM_018094 NP_060564.2 Q8IYD1 |
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