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Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Gene Name: | G1 to S phase transition 1 |
Synonyms: | GSPT1, 551G9.2, ETF3A, ERF3a, G1 to S phase transition 1, GST1 |
Target Sequences: | NM_002094 NP_002085.2 P15170 |
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