GSK3A / GSK3 Alpha

glycogen synthase kinase 3 alpha

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

GSK3A / GSK3 Alpha (7)

Publications

No (7)

Tag

GST, N-terminus (1)

His (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Rat GSK3A / GSK3 Alpha Protein (Recombinant His) (aa122-416) - LS-G24069

Source:

E. coli

Tag:

His

Molecular Weight:

37.4 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human GSK3A / GSK3 Alpha Protein (Recombinant GST, N-terminus) (aa393-483) - LS-G58770

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GSK3A / GSK3 Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65765

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.8 kDa

Price:

20 µg/$1,107

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Human GSK3A / GSK3 Alpha Protein (Recombinant His-GST) (aa115-409) - LS-G12518

Source:

E. coli

Tag:

His-GST

Molecular Weight:

65.8 kDa

Price:

10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113

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Mouse GSK3A / GSK3 Alpha Protein (Recombinant His-T7) (aa122-406) - LS-G12533

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.5 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human GSK3A / GSK3 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76237

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.8 kDa

Price:

20 µg/$150

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GSK3A / GSK3 Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111356

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.8 kDa

Price:

100 µg/$494

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