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Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Gene Name: | gastrin-releasing peptide receptor |
Family/Subfamily: | GPCR , Bombesin |
Synonyms: | GRPR, GRP-R, Bombesin BB2 receptor, GRP receptor, Grp/bombesin receptor |
Target Sequences: | NM_005314 NP_005305.1 P30550 |
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