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GRN / Granulin

granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Gene Name: granulin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: GRN, Acrogranin, CLN11, Epithelin precursor, GEP, gp88, Granulin, Granulin-epithelin, Granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin
Target Sequences: NM_002087 NP_002078.1 P28799

Publications (1)

1
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. Holler CJ, Taylor G, Deng Q, Kukar T. eNeuro. 2017 August;4: [Full Text Article] [PubMed:28828399] [PMC:PMC5562298] Related Antibodies: LS-C154960.

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GRN / Granulin (37)
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Mouse (12)
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Plasma (30)
Saliva (1)
Serum (31)
Tissue Homogenates (7)
Urine (2)
GRN / Granulin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
20.58 - 15000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
GRN / Granulin ELISA Kit
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Sandwich
96-Well Microplate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Breast Milk, Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$699
GRN / Granulin ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GRN / Granulin ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
GRN / Granulin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.102 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
GRN / Granulin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$783
GRN / Granulin ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
GRN / Granulin ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
GRN / Granulin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
GRN / Granulin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GRN / Granulin ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GRN / Granulin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.469 - 30 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
4.7 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$897
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GRN / Granulin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).