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GRM5 / MGLUR5
glutamate receptor, metabotropic 5
Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia. Summary of expresson: GRM5 has been reported to be expressed in various regions of the brain as well as in the spinal cord and dorsal root ganglia.
| Gene Name: | glutamate receptor, metabotropic 5 |
| Family/Subfamily: | GPCR , Metabotropic glutamate |
| Synonyms: | GRM5, GPRC1E, MGLUR5, Mglur5b, MGlu5 |
| Target Sequences: | NM_000842 NP_000833.1 P41594 |
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