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Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Gene Name: | G protein-coupled receptor kinase 4 |
Family/Subfamily: | Protein Kinase , GPRK |
Synonyms: | GRK4, GPRK4, GPRK2L, GRK4a, IT11, ITI1 |
Target Sequences: | NM_182982 NP_892027.2 P32298 |
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