GREM1 / Gremlin-1

gremlin 1, DAN family BMP antagonist

GREM1 / Gremlin-1 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (16)

Type

Over-Expression Lysate (2)

Recombinant (14)

Target

GREM1 / Gremlin-1 (16)

Publications

No (16)

Tag

10His, N-terminus + Myc, C-terminus (2)

6His, C-terminus (1)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (2)

His (1)

His, N-Terminal (1)

His-S (2)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Chicken (1)

Human (8)

Mouse (1)

Rat (5)

Source

293T Cells (1)

Baculovirus (1)

CHO Cells (1)

E. coli (8)

HEK 293 Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (3)

Purification

Purified (8)

Low Endotoxin Level

Low endotoxin level (1)

Biologically Active

Biologically active (1)

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Mouse GREM1 / Gremlin-1 Protein (Recombinant His, N-Terminal) (Lys25-Asp184) - LS-G14782

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

23.9 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Rat GREM1 / Gremlin-1 Protein (Recombinant His-T7) (aa25-184) - LS-G14786

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.1 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human GREM1 / Gremlin-1 Protein (Recombinant) - LS-G107

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

18.3 kDa

Price:

10 µg/$268; 50 µg/$349

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Human GREM1 / Gremlin-1 Protein (Recombinant GST) (Full Length) - LS-G33200

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.1 kDa

Price:

2 µg/$439

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Human GREM1 / Gremlin-1 Protein (Recombinant GST, N-terminus) (aa75-184) - LS-G62201

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human GREM1 / Gremlin-1 Protein (Recombinant GST, N-terminus) (aa25-124) - LS-G62203

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GREM1 / Gremlin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83419

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.7 kDa

Price:

20 µg/$150

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GREM1 / Gremlin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114298

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.7 kDa

Price:

100 µg/$494

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Rat GREM1 / Gremlin-1 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G136842

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

22.2 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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Rat GREM1 / Gremlin-1 Protein (Recombinant 6His, C-terminus) (Full Length) - LS-G137034

Source:

E. coli

Tag:

6His, C-terminus

Molecular Weight:

20.2 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat GREM1 / Gremlin-1 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G136547

Source:

Mammalian Cells

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

22.2 kDa

Price:

100 µg/$1,374; 20 µg/$543; 1 mg/$5,176

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Rat GREM1 / Gremlin-1 Protein (Recombinant 6His-SUMO, N-terminus) (aa25-184) - LS-G56304

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human GREM1 / Gremlin-1 Protein (Recombinant His) - LS-G2176

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human GREM1 / Gremlin-1 Protein (Recombinant His-T7) (aa26-184) - LS-G14783

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.0 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human GREM1 / Gremlin-1 Protein (Recombinant His-S) (aa26-184) - LS-G14784

Source:

E. coli

Tag:

His-S

Molecular Weight:

23.9 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Chicken GREM1 / Gremlin-1 Protein (Recombinant His-S) (aa27-184) - LS-G14785

Source:

E. coli

Tag:

His-S

Molecular Weight:

24.1 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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