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GREM1 / Gremlin-1

gremlin 1, DAN family BMP antagonist

GREM1 / Gremlin-1 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: gremlin 1, DAN family BMP antagonist
Synonyms: GREM1, CKTSF1B1, DAN domain family member 2, DAND2, DRM, GREMLIN, Gremlin 1-like protein, Increased in high glucose-2, Gremlin-1, PIG2, Proliferation-inducing gene 2, Gremlin 1, IHG-2
Target Sequences: NM_013372 NP_037504.1 O60565

Publications (3)

1
Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-?B pathway. Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T. Nature communications. 2019 March;10:1442. [Full Text Article] [PubMed:30926814] [PMC:PMC6441020] Related Antibodies: LS-C125371.
2
Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation. Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose, AnneMarie C Brescia. Pediatric rheumatology online journal. 2020 November;18:89. [Full Text Article] [PubMed:33198759] [PMC:PMC7670793]
3
Gremlin-1 for the Differential Diagnosis of Idiopathic Pulmonary Fibrosis Versus Other Interstitial Lung Diseases: A Clinical and Pathophysiological Analysis. Yoichiro Aoshima , Yasunori Enomoto, Shigeki Muto, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Takafumi Suda, Toshihide Iwashita. Lung. 2021 Jun;;199:289-298. [Full Text Article] [PubMed:33770226] [PMC:PMC8203516]

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Products
ELISA Kits (27)
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GREM1 / Gremlin-1 (27)
Human (6)
Mouse (8)
Rat (7)
Chicken (2)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (5)
96-Well Strip Plate (20)
No (25)
Yes (2)
Cell Culture Supernatants (3)
Cell Lysates (2)
Plasma (19)
Serum (19)
Tissue Homogenates (6)
Urine (1)
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$730
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GREM1 / Gremlin-1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GREM1 / Gremlin-1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.819 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
GREM1 / Gremlin-1 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
GREM1 / Gremlin-1 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
GREM1 / Gremlin-1 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
93.8 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$582
GREM1 / Gremlin-1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
GREM1 / Gremlin-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
GREM1 / Gremlin-1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$783
GREM1 / Gremlin-1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).