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GREM1 / Gremlin-1
gremlin 1, DAN family BMP antagonist
GREM1 / Gremlin-1 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | gremlin 1, DAN family BMP antagonist |
| Synonyms: | GREM1, CKTSF1B1, DAN domain family member 2, DAND2, DRM, GREMLIN, Gremlin 1-like protein, Increased in high glucose-2, Gremlin-1, PIG2, Proliferation-inducing gene 2, Gremlin 1, IHG-2 |
| Target Sequences: | NM_013372 NP_037504.1 O60565 |
Publications (3)
1
Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-?B pathway. Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T. Nature communications. 2019 March;10:1442. [Full Text Article]
[PubMed:30926814]
[PMC:PMC6441020]
Related Antibodies: LS-C125371.
2
Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation. Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose, AnneMarie C Brescia. Pediatric rheumatology online journal. 2020 November;18:89. [Full Text Article]
[PubMed:33198759]
[PMC:PMC7670793]
3
Gremlin-1 for the Differential Diagnosis of Idiopathic Pulmonary Fibrosis Versus Other Interstitial Lung Diseases: A Clinical and Pathophysiological Analysis. Yoichiro Aoshima , Yasunori Enomoto, Shigeki Muto, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Takafumi Suda, Toshihide Iwashita. Lung. 2021 Jun;;199:289-298. [Full Text Article]
[PubMed:33770226]
[PMC:PMC8203516]
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GREM1 / Gremlin-1
(134)
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(71)
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(61)
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Biologically Active
Biologically active
(1)
Neuroscience
GREM1 / Gremlin-1 Rabbit anti-Rat Polyclonal (aa25-184) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
GREM1 / Gremlin-1 Mouse anti-Human Monoclonal (4C2) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$634
GREM1 / Gremlin-1 Rabbit anti-Mouse Polyclonal (aa147-175) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$575
GREM1 / Gremlin-1 Rabbit anti-Rat Polyclonal (aa51-100) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Human
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$730
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Neuroscience
GREM1 / Gremlin-1 Rabbit anti-Mouse Polyclonal (aa26-184) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Neuroscience
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal (aa26-184) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal (aa26-184) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
GREM1 / Gremlin-1 Mouse anti-Human Monoclonal (aa26-184) Antibody
Human
WB
Unconjugated
100 µl/$314; 200 µl/$359; 500 µl/$507; 1 ml/$581; 2 ml/$798; 5 ml/$1,296
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
E. coli
His, N-Terminal
23.9 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His-T7
22.1 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Fast Shipping
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal (aa111-139) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.3 kDa
10 µg/$268; 50 µg/$349
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal (aa147-175) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
GREM1 / Gremlin-1 Rabbit anti-Human Polyclonal (aa147-175) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
GREM1 / Gremlin-1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
GREM1 / Gremlin-1 Rabbit anti-Mouse Polyclonal (aa26-184) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
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