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Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Gene Name: | growth factor receptor-bound protein 14 |
Synonyms: | GRB14, GRB14 adapter protein, GRB 14 |
Target Sequences: | NM_004490 NP_004481.2 Q14449 |
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