GRB10

growth factor receptor-bound protein 10

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

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Antibodies (48)

ELISA Kits (17)

Proteins (14)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Over-Expression Lysate (9)

Primary (48)

Recombinant (5)

Sandwich (12)

Sandwich CLIA (3)

Target

GRB10 (79)

Reactivity

Human (56)

Mouse (19)

Rat (7)

Chicken (1)

Guinea pig (1)

Hamster (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Application

IHC (12)

IHC-P (5)

WB (42)

ELISA (12)

ICC (4)

IF (12)

IP (4)

Peptide-ELISA (2)

Host

rabbit (45)

mouse (3)

Isotype

IgG (31)

IgG1 (1)

IgG2a (1)

IgG2a,k (1)

Clonality

monoclonal mc (3)

polyclonal pc (45)

Clone

1A7 (1)

OTI5A6 (1)

OTI6G1 (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (4)

96-Well Strip Plate (11)

APC (1)

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FITC Conjugated (4)

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PE Conjugated (3)

Unconjugated (28)

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Epitope

aa392-594 (8)

pSer501/503 (5)

pTyr67 (4)

10-90 aa (2)

N-Terminus (2)

aa100-150 (2)

aa164-415 (2)

Leu63 (1)

aa1-30 (1)

aa1-50 (1)

aa33-82 (1)

p67 (1)

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Publications

No (79)

Sample Type

Adherent Cell Cultures (2)

Plasma (9)

Serum (9)

Tissue Homogenates (4)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (10)

Species

Human (10)

Source

293T Cells (4)

E. coli (1)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

GRB10 Antibody (aa33-82) LS-C117946

Antibody:

GRB10 Rabbit anti-Human Polyclonal (aa33-82) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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GRB10 Antibody LS-C153751

Antibody:

GRB10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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GRB10 Antibody (N-Terminus) LS-C413202

Antibody:

GRB10 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

Select

GRB10 Antibody LS-C670716

Antibody:

GRB10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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GRB10 Antibody LS-C665982

Antibody:

GRB10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

GRB10 Antibody (10-90 aa) LS-C381146

Antibody:

GRB10 Rabbit anti-Human Polyclonal (10-90 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

GRB10 Antibody (10-90 aa) LS-C383844

Antibody:

GRB10 Rabbit anti-Human Polyclonal (10-90 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

GRB10 Antibody (p67) LS-C822572

Antibody:

GRB10 Rabbit anti-Human Polyclonal (p67) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

GRB10 Antibody (Leu63) LS-C176598

Antibody:

GRB10 Rabbit anti-Human Polyclonal (Leu63) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

GRB10 Antibody (phospho-Tyr67) LS-C313594

Antibody:

GRB10 Rabbit anti-Human Polyclonal (pTyr67) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, WB

Format:

Unconjugated

Price:

100 µl/$391

Select

GRB10 Antibody (phospho-Tyr67) LS-C352271

Antibody:

GRB10 Rabbit anti-Human Polyclonal (pTyr67) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$315

Select

GRB10 Antibody (aa392-594) LS-C373369

Antibody:

GRB10 Rabbit anti-Human Polyclonal (aa392-594) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

GRB10 Antibody (aa164-415, clone OTI5A6) LS-C796338

Antibody:

GRB10 Mouse anti-Human Monoclonal (aa164-415) (OTI5A6) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

GRB10 Antibody (phospho-Tyr67) LS-C822574

Antibody:

GRB10 Rabbit anti-Human Polyclonal (pTyr67) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

GRB10 Antibody (phospho-Tyr67) LS-C199020

Antibody:

GRB10 Rabbit anti-Human Polyclonal (pTyr67) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

GRB10 Antibody (N-Terminus) LS-C7296

Antibody:

GRB10 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Hamster, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

Select

GRB10 Antibody (clone 1A7) LS-C197347

Antibody:

GRB10 Mouse anti-Human Monoclonal (1A7) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

GRB10 Antibody (aa100-150) LS-C286080

Antibody:

GRB10 Rabbit anti-Human Polyclonal (aa100-150) Antibody

Reactivity:

Human

Applications:

IHC, IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

GRB10 Antibody LS-C665979

Antibody:

GRB10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

GRB10 Antibody LS-C665980

Antibody:

GRB10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$386

Select

GRB10 Antibody LS-C665978

Antibody:

GRB10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$406

Select

GRB10 Antibody (aa100-150) LS-C286821

Antibody:

GRB10 Rabbit anti-Human Polyclonal (aa100-150) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

GRB10 Antibody (aa1-50) LS-C286079

Antibody:

GRB10 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

GRB10 Antibody (aa164-415, clone OTI6G1) LS-C796342

Antibody:

GRB10 Mouse anti-Human Monoclonal (aa164-415) (OTI6G1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

GRB10 Antibody (phospho-Ser503) LS-C190080

Antibody:

GRB10 Rabbit anti-Human Polyclonal (pSer503) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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