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GPX3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Gene Name: | glutathione peroxidase 3 (plasma) |
Synonyms: | GPX3, Glutathione peroxidase 3, GSHPx-3, GPXP, GSHPx-P, GPx-3, GPx-P, Plasma glutathione peroxidase |
Target Sequences: | NM_002084 NP_002075.2 P22352 |
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