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GPT2 / ALT2 is a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants.
Gene Name: | glutamic pyruvate transaminase (alanine aminotransferase) 2 |
Synonyms: | GPT2, Alanine aminotransferase 2, AAT2, ALT2, GPT 2 |
Target Sequences: | Q8TD30 Q8TD30 |
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