GPS1 / CSN1

G protein pathway suppressor 1

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

GPS1 / CSN1 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human GPS1 / CSN1 Protein (Recombinant GST, N-terminus) (aa390-491) - LS-G58739

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human GPS1 / CSN1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65667

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

20 µg/$1,107

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Human GPS1 / CSN1 Protein (Recombinant His-T7) (aa16-185) - LS-G25984

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.8 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human GPS1 / CSN1 Protein (Recombinant GST) (Full Length) - LS-G28707

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.88 kDa

Price:

10 µg/$479; 25 µg/$670

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Human GPS1 / CSN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75995

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.4 kDa

Price:

20 µg/$150

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Human GPS1 / CSN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75997

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

20 µg/$150

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GPS1 / CSN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116859

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.4 kDa

Price:

100 µg/$494

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GPS1 / CSN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102745

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

100 µg/$494

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